Breath diagnostics provides a non-invasive method to study the composition of volatile and non-volatile compounds in exhaled breath. Some of the individual compounds or a set of compounds can be reflective of disease state and are called biomarkers. The lack of methods standardization and the absence of optimized hardware are among the major problems in this developing field. A number of parameters are known to affect the composition of breath samples: sampling period, breathing pattern, collected fraction of the exhaled breath (alveolar versus total expired volume), collection device material, condensation temperature, sample contamination with saliva, sample transfer and storage.
This work contributes to optimization of breath sampling methodology and development of a portable, easy-to-use system that will be capable to detect a wide spectrum of non-volatile compounds. Optimal exhaled breath sampling hardware and methodology were developed. Once optimized, the sampling module was designed for miniaturization and integration with modules for chemical analysis. A MEMS-based Capillary Electrophoresis – Electrospray system was designed and built for use in a portable platform for collection and processing of non-volatile biomarkers in exhaled breath. All modules were designed for integration into one portable system. Future development may include integration with detection sensors, such as currently available micro Ion Mobility Spectrometer or Differential Mobility Spectrometer.
Date(s) - 05/05/2017
12:15 am - 1:15 am
2130 Bainer - MAE Conference Room