Skip directly to: Navigation for this section | Main page content

Bioinstrumentation and BioMEMS Laboratory

Research Highlight:

Photo

Biosensors produce complex outputs which we interpret using machine learning algorithms. We can then visualize grouping of data based on patterns of biomarkers from the original samples.

PUBLICATIONS

Thank you for taking the time to look through our published work.

2013

Zrodnikov Y, Zamuruyev K, Pedersen JD, Fung AG, Peirano DJ, Schirle MJ, Panigrahy A, Pasamontes A, Cheung WHK, Aksenov AA, Schivo M, Kenyon NJ, Delplanque JP, Davis CE*. (2013) Design criteria for portable point-of-care breath analysis systems. Proceedings of 17th International Conference on Solid-State Sensors, Actuators and Microsystems 16-20 JUN 2013, Barcelona, Spain.

Straume T*, Loftus DJ, Li J, Coleman MA, Davis CE, McMonigal KA, Piccini M, Singh AK. (2013) Biomarker-detection technologies for comprehensive medical diagnosis during deep-space missions. Recent Advances in Space Biotechnology (in press)

Hunt KE*, Moore MJ, Rolland RM, Kellar N, Hall AJ, Kershaw J, Raverty SA, Davis CE, Yeates L, Fauquier D, Kraus S. (2013) Opening the biggest black box: new approaches to the study of conservation physiology of large whales. Conservation Physiology (in press)

Aksenov AA, Guaman Novillo AV, Sankaran S, Fung AG, Pasamontes A, Martinelli F, Cheung WHK, Eshani R, Dandekar AM, Davis CE*. (2013) Volatile Organic Compounds (VOCs) for Non-Invasive Plant Diagnostics. Natural Products for Pest Management (ed. John Beck). ACS Symposium Book Series, American Chemical Society (in press)

Peirano DJ, Aksenov AA, Pasamontes A, Davis CE*. (2013) Approaches for Establishing Methodologies in Metabolomic Studies for Clinical Diagnostics. Medical Applications of Artificial Intelligence (ed. Arvin Agah). CRC Press, Taylor Francis Group. (in press)

Schivo M, Seichter F, Aksenov AA, Pasamontes A, Peirano DJ, Mizaikoff B, Kenyon NJ, Davis CE*. (2013) Mobile instrumentation platform to distinguish airway disorders. Journal of Breath Research 7(1):017113. doi: 10.1088/1752-7155/7/1/017113.

Aksenov AA, Schivo M, Bardaweel H, Zrodnikov Y, Kwan AM, Zamuruyev K, Cheung WHK, Peirano DJ, Davis CE*. (2013) Chapter 8. Volatile organic compounds in human breath: biogenic origin and point-of-care analysis approaches. Volatile Biomarkers: Non-invasive Diagnosis in Physiology and Medicine (ed. David Smith, Anton Amann). pp. 129-154. Elsevier. ISBN: 978-0-444-62613-4.

2012

Bardaweel H, Zamuruyev K, Delplanque JP, Kenyon NJ, Carron C, Brand O, Davis CE*. (2012) Microscale surface energy properties for enhanced surface condensation and sampling of exhaled breath metabolites. Technical Digest: Solid-State Sensors, Actuators, and Microsystems Workshop Editors Mehregany M, Monk DJ. 2012 Hilton Head, SC, USA. 03-07 JUN 2012. pp. 239-242.

Aksenov AA, Kapron J, Davis CE. (2012) Predicting compensation voltage for singly-charged ions in high-field asymmetric waveform ion mobility spectrometry (FAIMS). Journal of The American Society for Mass Spectrometry 23(10): 1794-1798.

Martinelli F, Uratsu S, Albrecht U, Reagan RL, Phu ML, Britton M, Buffalo V, Fass J, Leicht E, Zhao W, Lin D, D'Souza R, Davis CE, Bowman KD, Dandekar AM*. (2012) Transcriptome profiling of citrus fruit in response to Huanglongbing disease. PLoS ONE 7(5): e38039

Zrodnikov Y, Davis CE*. (2012) The highs and lows of FAIMS: predictions and future trends for high field asymmetric waveform ion mobility spectrometry. Journal of Nanomedicine and Nanotechnology Volume 3, Issue 5: e109. (doi:10.4172/2157-7439.1000e109)

Aksenov AA§, Gojova A§, Zhao W, Morgan JT, Sankaran S, Sandrock C, Davis CE*. (2012) Characterization of volatile organic compounds in human leukocyte antigen heterologous expression systems: a cell's "chemical odor fingerprint" (§joint first authors) Chem Bio Chem 13(7): 1053–1059

Aksenov AA, Cheung WHK, Zhao W, Bardaweel H, Martinelli F, Fiehn O, Dandekar AM, Davis CE*. (2012) Reagentless detection of citrus pathogens using differential mobility spectrometry. Citrograph 3(2): 54-56.

Lay-Ekuakille A, Davis CE, Kanoun O, Li Z, Trabacca A. (2012) Editorial: Special Issue on Sensors for noninvasive physiological monitoring. IEEE Sensors Journal 12(3): 413-414.

Bumatay A§, Chan R§, Lauher K§, Kwan AM, Stoltz T, Delplanque JP, Kenyon NJ, Davis CE*. (2012) Coupled mobile phone platform with peak flow meter enables real-time lung function assessment. (§joint first authors) IEEE Sensors Journal 12(3): 685-691.

Panigrahy A, Delplanque JP, Davis CE*. (2012) Chapter 7: Future directions for breath sensors. Integrated Microsystems and Nanotechnology: MEMS, Biological, Photonics and Sensors Platform. (editor K. Iniewski). pp. 171-199. CRC Press, Taylor Francis Group. ISBN: 978-1439836200.

2011

Zhao W, Davis CE*. (2011) A modified artificial immune system based pattern recognition approach - An application to clinical diagnostics. Artificial Intelligence in Medicine 52(1): 1-9.

Schivo M, Akesnov AA, Bardaweel H, Zhao W, Kenyon NJ, Davis CE*. (2011) Building biomarker libraries with novel chemical sensors: correlating differential mobility spectrometer signal outputs with mass spectrometry data. IOP Conference Series: Materials Science and Engineering 18 (2011) 212003 (doi:10.1088/1757-899X/18/21/212003)

Dandekar AM*, Martinelli F, Zhao W, Bhushan A, Davis CE, Skogerson K, Fiehn O, Leicht E, D'Souza R. (2011) Non-destructive disease detection in citrus through the analysis of induced volatile organic compounds. Citrograph 1(5):17-20.

Fortenko O, Zeki A, Schuster G, Davis CE, Allayee H, Stephensen CB, Kenyon NJ*. (2011) Can fish oil supplements be used to treat severe asthmatic patients? California Agriculture 65(3): 106-111.

2010

Bhushan A, Han H, Sutherland A, Boehme S, Yaghmaie F, Davis CE*. (2010) Generation of paramagnetic hybrid inorganic/organic thin films. Applied Organometallic Chemistry 24(7): 530-532.

Dandekar AM*, Martinelli F, Davis CE, Bhushan A, Zhao W, Fiehn O, Skogerson K, Wohlgemuth G, D'Souza R, Roy S, Reagan R, Lin D, Bruening G, Cary RB, Pardington P, Gupta G. (2010) Analysis of early host responses for asymptomatic disease detection and management of specialty crops. Critical Reviews in Immunology 30(3): 277-289.

Sankaran S, Mishra AR, Ehsani R*, Davis CE. (2010) A review of advanced techniques for detecting plant diseases. Computers and Electronics in Agriculture 72: 1-13.

Han H, Bhushan A, Yaghmaie F, Davis CE*. (2010) Direct thermal-UV nanoimprint of an iron-containing organometallic hybrid film. Journal of Vacuum Science and Technology - Part B 28(1): 78-81.

Strand N, Bhushan A, Schivo M, Kenyon N, Davis CE*. (2010) Chemically polymerized polypyrrole for on-chip concentration of volatile breath metabolites. Sensors and Actuators B 143(2): 516-523.

Han H, Bissell J, Yaghmaie F, Davis CE*. (2010) Polymeric acrylate-based hybrid films containing lead and iron patterned by UV photo-polymerization. Langmuir 26(1): 515-520.

Nording M, Yang J, Hegedus CM, Bhushan A, Kenyon NJ, Davis CE, Hammock BD*. (2010) Endogenous levels of five fatty acid metabolites in exhaled breath condensate to monitor for asthma by high-performance liquid chromatography electrospray tandem mass spectrometry. IEEE Sensors Journal special issue "Sensors for Breath Analysis" 10(1): 123-130.

Davis CE*, Bogan MJ, Sankaran S, Molina MA, Loyola BR, Zhao W, Benner WH, Schivo M, Farquar GR, Kenyon NJ, Frank M. (2010) Volatile and non-volatile analysis of biomarkers in human breath using differential mobility spectrometry. IEEE Sensors Journal special issue "Sensors for Breath Analysis" 10(1): 114-122.

Davis CE*, Frank M*, Mizaikoff B*, Oser H*. (2010) EDITORIAL: The future of sensors and instrumentation for human breath analysis. IEEE Sensors Journal special issue "Sensors for Breath Analysis" 10(1): 3-6.

Zhao W, Davis CE*. (2010) Ant colony optimization: a powerful strategy for biomarker feature selection. Swarm Intelligence. (editor L.P. Waters) Nova Science Publishers, Inc. (Hauppauge, NY). ISBN: 978-1-61728-602-5

Zhao W, Bhushan A, Schivo M, Kenyon NJ, Davis CE*. (2010) Miniature differential mobility spectrometry (DMS) advances towards portable autonomous health diagnostic systems. Wearable and Autonomous Biomedical Devices and Systems: New issues and Characterization. (editors S.C. Mukhopadhyay and A. Lay-Ekuakille) pp. 144-165. Springer-Verlag (Berlin, Heidelberg), ISBN: 978-3-642-05166-1.

Simon MG, Davis CE*. (2010) "Instrumentation and sensors for human breath analysis." Advances in Biomedical Sensing, Measurements, Instrumentation and Systems (eds. S.C. Mukhopadhyay and A. Lay-Ekuakille) pp. 144-165. Springer-Verlag Publishers (Berlin, Heidelberg). ISBN: 978-3-642-05166-1

Bhushan A, Davis CE*. (2010) "Chapter 29: Silicon based Bio-MEMS Devices: Micromachining Technologies" Handbook of Silicon Based MEMS Materials and Technologies (editors V. Lindroos, M. Tilli, A. Lehto, T. Motooka) pp. 489-498. Elsevier Publishers. ISBN: 978-0-8155-1594-4.

2009

Zhao W, Davis CE*. (2009) Swarm intelligence based wavelet coefficient feature selection for mass spectral classification: an application to proteomics data. (2009) Analytica Chimica Acta 651(1): 15-23. (paper reviewed and highlighted in feature article for SeparationNOW)

Strand NC, Davis CE*. (2009) Analytical methods in exhaled breath diagnostics. Separation Science 1(4): 20-28. (feature article, cover of issue)

Zhao W, Sankaran S, Ibanez AM, Dandekar AM, Davis CE*. (2009) Two-dimensional wavelet analysis based classification of gas chromatogram differential mobility spectrometry signals. Analytica Chimica Acta 647: 46-53.

Zhao W, Davis CE*. (2009) Autoregressive model based feature extraction method for time shifted chromatography data. Chemometrics and Intelligent Laboratory Systems 96(2): 252-257.

Han H, Sutherland A, Yaghmaie F, Davis CE*. (2009) Development of a lead oxide photopatternable organic-inorganic film. Applied Physics Letters 94(14): 144106.

Yaghmaie F, Nielsen W, Han H, Bhushan A, Davis CE*. (2009) A simplified method to produce a functional test stamp for nanoimprint lithography (NIL). IEEE Sensors Journal 9(3): 233-234.

Katzenmeyer AM, Bayam Y, Logeeswaran VJ, Pitcher MW, Nur Y, Seyyidoglu S, Toppare LK, Talin AA, Han H, Davis CE, Islam MS*. (2009) Poly(hydridocarbyne) as a highly processable insulating polymer precursor to micro/nanostructures and graphite conductors. Journal of Nanomaterials 2009: 1-4. (doi:10.1155/2009/832327)

Cardona CJ*, Xing Z, Sandrock CE, Davis CE. (2009) Avian influenza in birds and animals. Comparative Immunology, Microbiology and Infectious Diseases 32(4): 255-273.

2008

Molina M, Zhao W, Sankaran S, Schivo M, Kenyon NJ, Davis CE*. (2008) Design-of-experiment optimization of exhaled breath condensate analysis using a miniature differential mobility spectrometer (DMS). Analytica Chimica Acta 628: 155-161.

Loyola B, Bhushan A, Schivo M, Kenyon NJ, Davis CE*. (2008) Temperature changes in exhaled breath condensate collection devices may affect observed biomarker concentrations. Journal of Breath Research 2: 1-7. (doi: 10.1088/1752-7155/2/3/037005)

Ayer S, Zhao W, Davis CE*. (2008) Differentiation of proteins and viruses using pyrolysis gas chromatography differential mobility spectrometry (PY/GC/DMS) and pattern recognition. IEEE Sensors Journal 8(9): 1586-1592.

Zhao W, Bhushan A, Simon M, Santamaria A, Davis CE*. (2008) Machine learning: a crucial tool for developing sensors. Algorithms 1(2): 130-152.

Zhao W, Morgan JT, Davis CE*. (2008) Chemical sensor output classification based on complex coefficients of an autoregressive model. Journal of Sensors 2008: 1-8. [doi:10.1155/2008/262501]

Katzenmeyer AM, Bayam Y, Logeeswaran VJ, Pitcher MW, Nur Y, Seyyidoglu S, Toppare LK, Talin AA, Han H, Davis CE, Islam MS*. (2008) Poly(hydridocarbyne) as a highly processable insulating polymer precursor to micro/nanostructures and graphite conductors. The 8th International Conference on Nanotechnology 1: 1-3.

Abramowitch S, Cooper R, Dasco C, Davis C, Hampapur A, Mataric M, Peckham H, Wanagat J, Weinrich M, Barron N. (2008) "Develop Technological Interventions to Overcome Barriers to Independence and Community Participation" The National Academies Keck Futures Initiative: The Future of Human Healthspan: Demography, Evolution, Medicine, and Bioengineering, Task Group Summaries. The National Academies Press (Washington, DC), pp. 57-72. ISBN: 10: 0309115590.

2007

Sankaran S, Loyola B, Zhao W, Morgan JT, Molina M, Schivo M, Kenyon NJ, Davis CE*. (2007) Micromachined differential mobility spectrometers for breath analysis. Sensors, 2007 IEEE 1: 16-19.

Frank M*, Farquar G, Adams C, Bogan M, Martin A, Benner H, Spadaccini C, Steele P, Sankaran S, Loyola B, Morgan J, Davis CE. (2007) Modular sampling and analysis techniques for real-time analysis of human breath. Sensors, 2007 IEEE 1: 10-13.

Zhao W, Davis CE*. (2007) "Pattern recognition algorithms to analyze data outputs from novel E-nose sensors", Pattern Recognition in Nanoscience (editor D.M. Perez) Nova Science Publishers, Inc. (Hauppauge, NY), pp. 1-32. ISBN: 978-1-60021-715-9

Han Huilan, Davis CE*. (2007) Tutorial on chip-based electrophysiology to assess ion channel function. Nanomaterials Synthesis, Interfacing, and Integrating in Devices, Circuits, and Systems II. Proceedings of SPIE 6768(26): 1-10.

2006

Morgan JT, Davis CE*. (2006) Differential mobility spectrometry applications in homeland security, clinical diagnostics and drug discovery. 2006 ASME International Mechanical Engineering Congress and Exposition. November 5-10, 2006, Chicago, Illinois. IMECE2006-15937.

Krebs MD, Cohen SJ, Lowzo J, Kang J, Tingley RD, Davis CE*. (2006) Two-dimensional alignment of differential mobility spectrometer data. Sensors and Actuators B - Chemical 119: 475-482.

Krebs MD, Mansfield B, Yip P, Cohen SJ, Sonenshein AL, Hitt B, Davis CE*. (2006) Spore biomarkers differentiate between closely-related Bacillus species using differential mobility spectrometry. Biomolecular Engineering 23(2): 119-127.

Krebs MD, Tingley RD, Kang J, Zeskind JE, Holmboe ME, Davis CE*. (2006) Alignment of analytical sensor data by landmark selection from complex chemical mixtures. Chemometrics and Intelligent Laboratory Systems 81(1): 74-81.

2005

Shnayderman M, Mansfield B, Yip P, Clark HA, Krebs MD, Cohen SJ, Zeskind JE, Ryan ET, Dorkin HL, Callahan MV, Stair TO, Gelfand JA, Gill CJ, Hitt B, Davis CE*. (2005) Species-specific bacteria identification using differential mobility spectrometry and bioinformatics pattern recognition. Analytical Chemistry 77(18): 5930-5937.

Krebs MD, Zapata AM, Nazarov EG, Miller RA, Costa IS, Sonenshein AL, Davis CE*. (2005) Detection of biological and chemical agents using differential mobility spectrometry (DMS). IEEE Sensors Journal, Special Edition on Anti-Terrorism 5(4): 696-703.

2004

Krebs MD, Tingley RD, Zeskind JE, Kang JM, Holmboe ME, Davis CE*. (2004) Autoregressive modeling of analytical sensor data can yield classifiers in the predictor coefficient parameter space. Bioinformatics 21(8): 1325-31.

Davis CE, Patel MK, Miller JR, Tucker AL, Mounsey JP, Jones LR, Moorman JR*. (2004) Swelling-activated ion currents and volume regulation of embryonic kidney cells: effects of phospholemman expression. Neurochemical Research 29(1): 177-187.

Davis CE, Rychak JJ, Hosticka B, Davis SC, John JE, Norris PM, Moorman JR*. (2004) A novel technique to measure dynamic cell volume changes. Journal of Applied Physiology 96(5): 1886-1893.

2003 and earlier...

Davis CE*, Kang JM, Dubé CE, Borenstein JT, Nazarov EG, Miller RA, Zapata AM. (2003) Spore biomarker detection using a MEMS Differential Mobility Spectrometer. The 12th IEEE International Conference on Solid-State Sensors and Microsystems Conference, IEEE Proceedings Vol 2: 1233-1238.

Blain-Christen JM, Davis CE, Li M, Andreou AG*. (2002) Robust Polymeric Techniques for Design, Post-processing and Packaging Arrays of Bio-MEMS Devices. Proceedings from The Tenth Meeting of the Symposium on Polymers for Microelectronics. Vol 1: 700-703.

Blain-Christen JM, Davis CE, Li M, Andreou AG*. (2002) Design, double sided post-processing, and packaging of CMOS compatible bio-MEMS device arrays. Circuits and Systems, 2002. ISCAS 2002. IEEE International Symposium on Circuits and Systems. Vol 1: 665-668.

§Kao WY, §Davis CE, Kim YI, Beach JM*. (2001) Fluorescence emission spectral shift measurements of membrane potential in single cells. (§joint first authors). Biophysical Journal 81(2):1163-70.

Kim YI*, Joo C, Cheng CC, Davis CE, O'Shaughnessy TJ. (1996) Neuromuscular transmission in a transgenic animal model of motor neuron disease. Annual International Conference of the IEEE Engineering in Medicine and Biology. IEEE Press, Piscataway, NJ, IEEE Proceedings Vol 4: 1773-1775.

Issued Patents

Zapata AM, Kim ES, Agrawal P, Krebs MD, Davis CE. Apparatus and systems for processing samples for analysis via ion mobility spectrometry. Issued 29 JUN 2011. US Patent #7,968,842.

Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. Issued 18 AUG 2009. US Patent #7,576,319.

Merrick WF, Zeskind JE, Krebs MD, Davis CE. Monitoring drinking water quality using differential mobility spectrometry. Issued 30 DEC 2008. US Patent #7,470,898.

Zapata AM, Kim ES, Agrawal P, Krebs MD, Davis CE. Apparatus and systems for processing samples for analysis via ion mobility spectrometry. Issued 17 JUN 2008. US Patent #7,388,195.

Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. Issued 08 APR 2008. US Patent #7,355,170.

Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. Issued 06 JUN 2006. US Patent #7,057,168.

Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. Issued 10 JUL 2007. US Patent #7,241,989.

Pending Patents

Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. (Filed with EU on 23 SEP 2004) PCT Patent Application #EP1601948 (World Patent Reference #WO 2004/081527 A2).

Davis CE, Borenstein JT, Zapata AM, Gelfand JA, Callahan MV, Stair TO, Miller RA. Non-invasive breath analysis using field asymmetric ion mobility spectrometry. (Filed with EU on 21 OCT 2004) PCT Patent Application #EP1627223 (World Patent Reference #WO 2004/090534 A1).

Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. (Filed with USPTO on 10 MAR 2005) US Patent Application # 20050051719.

Davis CE, Borenstein JT, Zapata AM, Gelfand JA, Callahan MV, Stair TO, Miller RA. Non-invasive breath analysis using field asymmetric ion mobility spectrometry. (Filed with USPTO on 21 APR 2005) US Patent Application # 20050085740.

Davis CE, Tingley RD, Krebs MD. Alignment and autoregressive modeling of analytical sensor data from complex chemical mixtures. (Filed with USPTO on 26 JAN 2006) US Patent Application #20060020401.

Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. (Filed with USPTO on 13 JUL 2006) US Patent Application #20060151687.

Zapata AM, Kim ES, Agrawal P, Krebs MD, Davis CE. Apparatus and systems for processing samples for analysis via ion mobility spectrometry. (Filed with USPTO on 27 JUL 2006) US Patent Application #20060163471.

Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. (Filed with USPTO on 29 MAY 2007) US Patent Application # 20070228269.

Merrick WF, Zeskind JE, Krebs MD, Davis CE. Monitoring drinking water quality using differential mobility spectrometry. (Filed with USPTO on 12 APR 2007) US Patent Application #20070083127.

Davis CE, Yaghmaie F, Han H, Bhushan A. Synthesis and application of photosensitive/patternable hybrid films containing silicones and organo-metallics. PCT publication WO 09/086184 (09 JUL 2009)

Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. (Filed with USPTO on 05 JUN 2008) US Patent Application # 20080128609.

Zapata AM, Kim ES, Agrawal P, Krebs MD, Davis CE. Apparatus and systems for processing samples for analysis via ion mobility spectrometry. (Filed with USPTO on 26 MAR 2009) US Patent Application #20090078865.

Davis CE, Fiehn O, Dandekar AM, Aksenov AA, Zhao W, Cheung WHK, Martinelli F, Skogerson K. Disease detection in plants. (Filed with USPTO on 21 MAR 2011) U.S. Patent Application 61/465,649.

Davis CE, Bardaweel H, Zamuruyev K, Delplanque JP, Kenyon NJ. MEMS-based exhaled breath sampler. (Filed with USPTO on 25 JAN 2012) U.S. Patent Application 61/590,691.

Davis CE, Bardaweel H, Zamuruyev K, Delplanque JP, Kenyon NJ. Microreactor for on-chip biochemical analysis. (Filed with USPTO on 25 JAN 2012) U.S. Patent Application 61/590,694.