Research Highlight:
Biosensors produce complex outputs which we interpret using machine learning algorithms. We can then visualize grouping of data based on patterns of biomarkers from the original samples.
PUBLICATIONS
Thank you for taking the time to look through our published work.
2009
Han H, Bhushan A, Yaghmaie F, Davis CE*. Direct Thermal-UV Nanoimprint of an Iron-Containing Organometallic Hybrid Film. Journal of Vacuum Science and Technology - Part A (accepted, in press)
Strand N, Bhushan A, Schivo M, Kenyon N, Davis CE*. Chemically polymerized polypyrrole for on-chip concentration of volatile breath metabolites. Sensors and Actuators B (accepted, in press)
Dandekar AM*, Martinelli F, Davis CE, Bhushan A, Zhao W, Fiehn O, Skogerson K, Wohlgemuth G, D'Souza R, Roy S, Reagan R, Lin D, Bruening G, Cary RB, Pardington P, Gupta G. Analysis of early host responses for asymptomatic disease detection and management of specialty crops. Critical Reviews in Immunology (accepted, in press)
Han H, Bissell J, Yaghmaie F, Davis CE*. Polymeric acrylate-based hybrid films containing lead and iron patterned by UV photo-polymerization. Langmuir (accepted, in press)
Davis CE*, Frank M*, Mizaikoff B*, Oser H*. EDITORIAL: The future of sensors and instrumentation for human breath analysis. IEEE Sensors Journal special issue "Sensors for Breath Analysis" (accepted, in press)
Nording M, Yang J, Hegedus CM, Bhushan A, Kenyon NJ, Davis CE, Hammock BD*. Endogenous levels of five fatty acid metabolites in exhaled breath condensate to monitor for asthma by high-performance liquid chromatography electrospray tandem mass spectrometry. IEEE Sensors Journal special issue "Sensors for Breath Analysis" (accepted, in press)
Davis CE*, Bogan MJ, Sankaran S, Molina MA, Loyola BR, Zhao W, Benner WH, Schivo M, Farquar GR, Kenyon NJ, Frank M. Volatile and non-volatile analysis of biomarkers in human breath using differential mobility spectrometry. IEEE Sensors Journal special issue "Sensors for Breath Analysis" (accepted, in press)
Zhao W, Davis CE*. Swarm intelligence based wavelet coefficient feature selection for mass spectral classification: an application to proteomics data. Analytica Chimica Acta 651(1): 15-23. (paper reviewed and highlighted in feature article for SeparationNOW)
Strand NC, Davis CE*. (2009) Analytical methods in exhaled breath diagnostics. Separation Science 1(4): 20-28. (feature article, cover of issue)
Zhao W, Sankaran S, Ibanez AM, Dandekar AM, Davis CE*. (2009) Two-dimensional wavelet analysis based classification of gas chromatogram differential mobility spectrometry signals. Analytica Chimica Acta 647: 46-53.
Zhao W, Davis CE*. (2009) Autoregressive model based feature extraction method for time shifted chromatography data. Chemometrics and Intelligent Laboratory Systems 96(2); 252-257.
Han H, Sutherland A, Yaghmaie F, Davis CE*. (2009) Development of a lead oxide photopatternable organic-inorganic film. Applied Physics Letters 94(14): 144106.
Yaghmaie F, Nielsen W, Han H, Bhushan A, Davis CE*. (2009) A simplified method to produce a functional test stamp for nanoimprint lithography (NIL). IEEE Sensors Journal 9(3): 233-234.
Katzenmeyer AM, Bayam Y, Logeeswaran VJ, Pitcher MW, Nur Y, Seyyidoglu S, Toppare LK, Talin AA, Han H, Davis CE, Islam MS*. (2009) Poly(hydridocarbyne) as a highly processable insulating polymer precursor to micro/nanostructures and graphite conductors. Journal of Nanomaterials 2009: 1-4. (doi:10.1155/2009/832327)
Cardona CJ*, Xing Z, Sandrock CE, Davis CE. (2009) Avian influenza in birds and animals. Comparative Immunology, Microbiology and Infectious Diseases 32(4): 255-273.
Simon MG, Davis CE*. (in press, 2009) "Instrumentation and Sensors for Human Breath Analysis." Advances in Biomedical Sensing, Measurements, Instrumentation and Systems (eds. S.C. Mukhopadhyay and A. Lay-Ekuakille) Springer-Verlag Publishers. ISBN: 978-3-642-05166-1
Bhushan A, Davis CE*. (2009) "Chapter 29: Silicon based Bio-MEMS Devices: Micromachining Technologies" Handbook of MEMS Materials and Technology (editors V. Lindroos, M. Tilli, A. Lehto, T. Motooka) Springer-Verlag Publishers. ISBN: 978-0-8155-1594-4
2008
Molina M, Zhao W, Sankaran S, Schivo M, Kenyon NJ, Davis CE*. (2008) Design-of-experiment optimization of exhaled breath condensate analysis using a miniature differential mobility spectrometer (DMS). Analytica Chimica Acta 628: 155-161.
Loyola B, Bhushan A, Schivo M, Kenyon NJ, Davis CE*. (2008) Temperature changes in exhaled breath condensate collection devices may affect observed biomarker concentrations. Journal of Breath Research 2: 1-7. (doi: 10.1088/1752-7155/2/3/037005)
Ayer S, Zhao W, Davis CE*. (2008) Differentiation of proteins and viruses using pyrolysis gas chromatography differential mobility spectrometry (PY/GC/DMS) and pattern recognition. IEEE Sensors Journal 8(9): 1586-1592.
Zhao W, Bhushan A, Simon M, Santamaria A, Davis CE*. (2008) Machine learning: a crucial tool for developing sensors. Algorithms 1(2): 130-152.
Zhao W, Morgan JT, Davis CE*. (2008) Chemical sensor output classification based on complex coefficients of an autoregressive model. Journal of Sensors 2008: 1-8. [doi:10.1155/2008/262501]
Katzenmeyer AM, Bayam Y, Logeeswaran VJ, Pitcher MW, Nur Y, Seyyidoglu S, Toppare LK, Talin AA, Han H, Davis CE, Islam MS*. (2008) Poly(hydridocarbyne) as a highly processable insulating polymer precursor to micro/nanostructures and graphite conductors. The 8th International Conference on Nanotechnology 1: 1-3.
Abramowitch S, Cooper R, Dasco C, Davis C, Hampapur A, Mataric M, Peckham H, Wanagat J, Weinrich M, Barron N. (2008) "Develop Technological Interventions to Overcome Barriers to Independence and Community Participation" The National Academies Keck Futures Initiative: The Future of Human Healthspan: Demography, Evolution, Medicine, and Bioengineering, Task Group Summaries. The National Academies Press (Washington, DC), pp. 57-72. ISBN: 10: 0309115590.
2007
Sankaran S, Loyola B, Zhao W, Morgan JT, Molina M, Schivo M, Kenyon NJ, Davis CE*. (2007) Micromachined differential mobility spectrometers for breath analysis. Sensors, 2007 IEEE 1: 16-19.
Frank M*, Farquar G, Adams C, Bogan M, Martin A, Benner H, Spadaccini C, Steele P, Sankaran S, Loyola B, Morgan J, Davis CE. (2007) Modular sampling and analysis techniques for real-time analysis of human breath. Sensors, 2007 IEEE 1: 10-13.
Zhao W, Davis CE*. (2007) "Pattern recognition algorithms to analyze data outputs from novel E-nose sensors", Pattern Recognition in Nanoscience (editor D.M. Perez) Nova Science Publishers, Inc. (Hauppauge, NY), pp. 1-32. ISBN: 978-1-60021-715-9
Han Huilan, Davis CE*. (2007) Tutorial on chip-based electrophysiology to assess ion channel function. Nanomaterials Synthesis, Interfacing, and Integrating in Devices, Circuits, and Systems II. Proceedings of SPIE 6768(26): 1-10.
2006
Morgan JT, Davis CE*. (2006) Differential mobility spectrometry applications in homeland security, clinical diagnostics and drug discovery. 2006 ASME International Mechanical Engineering Congress and Exposition. November 5-10, 2006, Chicago, Illinois. IMECE2006-15937.
Krebs MD, Cohen SJ, Lowzo J, Kang J, Tingley RD, Davis CE*. (2006) Two-dimensional alignment of differential mobility spectrometer data. Sensors and Actuators B - Chemical 119: 475-482.
Krebs MD, Mansfield B, Yip P, Cohen SJ, Sonenshein AL, Hitt B, Davis CE*. (2006) Spore biomarkers differentiate between closely-related Bacillus species using differential mobility spectrometry. Biomolecular Engineering 23(2): 119-127.
Krebs MD, Tingley RD, Kang J, Zeskind JE, Holmboe ME, Davis CE*. (2006) Alignment of analytical sensor data by landmark selection from complex chemical mixtures. Chemometrics and Intelligent Laboratory Systems 81(1): 74-81.
2005
Shnayderman M, Mansfield B, Yip P, Clark HA, Krebs MD, Cohen SJ, Zeskind JE, Ryan ET, Dorkin HL, Callahan MV, Stair TO, Gelfand JA, Gill CJ, Hitt B, Davis CE*. (2005) Species-specific bacteria identification using differential mobility spectrometry and bioinformatics pattern recognition. Analytical Chemistry 77(18): 5930-5937.
Krebs MD, Zapata AM, Nazarov EG, Miller RA, Costa IS, Sonenshein AL, Davis CE*. (2005) Detection of biological and chemical agents using differential mobility spectrometry (DMS). IEEE Sensors Journal, Special Edition on Anti-Terrorism 5(4): 696-703.
2004
Krebs MD, Tingley RD, Zeskind JE, Kang JM, Holmboe ME, Davis CE*. (2004) Autoregressive modeling of analytical sensor data can yield classifiers in the predictor coefficient parameter space. Bioinformatics 21(8): 1325-31.
Davis CE, Patel MK, Miller JR, Tucker AL, Mounsey JP, Jones LR, Moorman JR*. (2004) Swelling-activated ion currents and volume regulation of embryonic kidney cells: effects of phospholemman expression. Neurochemical Research 29(1): 177-187.
Davis CE, Rychak JJ, Hosticka B, Davis SC, John JE, Norris PM, Moorman JR*. (2004) A novel technique to measure dynamic cell volume changes. Journal of Applied Physiology 96(5): 1886-1893.
2003 and earlier...
Davis CE*, Kang JM, Dubé CE, Borenstein JT, Nazarov EG, Miller RA, Zapata AM. (2003) Spore biomarker detection using a MEMS Differential Mobility Spectrometer. The 12th IEEE International Conference on Solid-State Sensors and Microsystems Conference, IEEE Proceedings Vol 2: 1233-1238.
Blain-Christen JM, Davis CE, Li M, Andreou AG*. (2002) Robust Polymeric Techniques for Design, Post-processing and Packaging Arrays of Bio-MEMS Devices. Proceedings from The Tenth Meeting of the Symposium on Polymers for Microelectronics. Vol 1: 700-703.
Blain-Christen JM, Davis CE, Li M, Andreou AG*. (2002) Design, double sided post-processing, and packaging of CMOS compatible bio-MEMS device arrays. Circuits and Systems, 2002. ISCAS 2002. IEEE International Symposium on Circuits and Systems. Vol 1: 665-668.
§Kao WY, §Davis CE, Kim YI, Beach JM*. (2001) Fluorescence emission spectral shift measurements of membrane potential in single cells. (§joint first authors). Biophysical Journal 81(2):1163-70.
Kim YI*, Joo C, Cheng CC, Davis CE, O'Shaughnessy TJ. (1996) Neuromuscular transmission in a transgenic animal model of motor neuron disease. Annual International Conference of the IEEE Engineering in Medicine and Biology. IEEE Press, Piscataway, NJ, IEEE Proceedings Vol 4: 1773-1775.
Issued Patents
Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. Issued 08/18/2009. US Patent #7,576,319.
Merrick WF, Zeskind JE, Krebs MD, Davis CE. Monitoring drinking water quality using differential mobility spectrometry. Issued 12/30/2008. US Patent #7,470,898.
Zapata AM, Kim ES, Agrawal P, Krebs MD, Davis CE. Apparatus and systems for processing samples for analysis via ion mobility spectrometry. Issued 06/17/2008. US Patent #7,388,195.
Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. Issued 04/08/2008. US Patent #7,355,170.
Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. Issued 06/06/2006. US Patent #7,057,168.
Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. Issued 07/10/2007. US Patent #7,241,989.
Pending Patents
Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. (Filed with EU on 09/23/2004) PCT Patent Application #EP1601948 (World Patent Reference #WO 2004/081527 A2).
Davis CE, Borenstein JT, Zapata AM, Gelfand JA, Callahan MV, Stair TO, Miller RA. Non-invasive breath analysis using field asymmetric ion mobility spectrometry. (Filed with EU on 10/21/2004) PCT Patent Application #EP1627223 (World Patent Reference #WO 2004/090534 A1).
Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. (Filed with USPTO on 03/10/2005) US Patent Application # 20050051719.
Davis CE, Borenstein JT, Zapata AM, Gelfand JA, Callahan MV, Stair TO, Miller RA. Non-invasive breath analysis using field asymmetric ion mobility spectrometry. (Filed with USPTO on 04/21/2005) US Patent Application # 20050085740.
Davis CE, Tingley RD, Krebs MD. Alignment and autoregressive modeling of analytical sensor data from complex chemical mixtures. (Filed with USPTO on 01/26/2006) US Patent Application #20060020401.
Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. (Filed with USPTO on 07/13/2006) US Patent Application #20060151687.
Zapata AM, Kim ES, Agrawal P, Krebs MD, Davis CE. Apparatus and systems for processing samples for analysis via ion mobility spectrometry. (Filed with USPTO on 07/27/2006) US Patent Application #20060163471.
Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. (Filed with USPTO on 05/29/2007) US Patent Application # 20070228269.
Merrick WF, Zeskind JE, Krebs MD, Davis CE. Monitoring drinking water quality using differential mobility spectrometry. (Filed with USPTO on 04/12/2007) US Patent Application #20070083127.
Davis CE, Yaghmaie F, Han H, Bhushan A, Bissell J. Synthesis and application of photosensitive/patternable hybrid films containing silicones and organo-metallics. Patent pending.
Miller RA, Nazarov EG, Zapata AM, Davis CE, Eiceman GA, Bashall AD. Systems for differential ion mobility analysis. (Filed with USPTO on 06/05/2008) US Patent Application # 20080128609.
Zapata AM, Kim ES, Agrawal P, Krebs MD, Davis CE. Apparatus and systems for processing samples for analysis via ion mobility spectrometry. (Filed with USPTO on 03/26/2009) US Patent Application #20090078865.