The Biofluids and Cellular Mechanics Laboratory at UC Davis
Principal Investigator: Abdul I. Barakat

  e-mail PI






 

Papers:

Effect of Cerium Oxide Nanoparitcles on Inflammation in Vascular Endothelial Cells
Andrea Gojova, Jun-Tae Lee, Heejung S. Jung, Bing Guo, Abdul I. Barakat, and Ian M. Kennedy. Inhalation Toxicology, 2009, 21, pp. 123-130.

Dragging Along: The Glycocalyx and Vascular Endothelial Cell Mechanotransduction
Abdul I. Barakat. Circulation Research, 2008, 102,pp. 747-748.

Role of  Ultrasonic Shear Rate Estimation Errors in Assessing Inflammatory Response and Vascular Risk
Jean K. Tsou, Jie Liu, Abdul I. Barakat, and Michael F. Insana. Ultrasound in Medicine and Biology, 2008, In Press.

Shear Stress and 17beta-estradiol Modulate cerebral Microvascular Endothelial Na-K-Cl Cotransporter and Na/H Exchanger Protein Levels
Elain Chang, Martha E. O'Donnell, and Abdul I. Barakat. American Journal of Physiology, 2008, 294 pp. C363-371.

rophoblast and Shear Stress Induce an Asymmetric Distribution of ICAM-1 in the Uterine Endothelial Cells
Tim C. Cao, Twanda L. Thirkill, Mark Wells, Abdul I. Barakat, and Gordon C. Douglas. American Journal of Reproductive Immunology, 2008, 59 pp. 167-181.

MUC1 Is Involed in Trophoblast Transendothelial Migration
Twanda L. Thirkill, Tim Cao, Michael Stout, Thomas N. Blankenship, Abdul Barakat, and Gordon C. Douglas. Biochimica et Biophysica Acta, 2007, 1773 pp. 1007-1014.

Induction of Inflammation in Vascular Endothelial Cells by Metal Oxide Nanoparticles: Effect of Particle Compositon
Andrea Gojova, Bing Guo, Rama S. Kota, John C. Rutledge, Ian M. Kennedy, and Abdul I. Barakat, 2007, Environmental Health Prospectives, 115 pp. 403-409.

Initial Investigation of SU-8 photopolymer as a material for non-invasive endothelial cell research platforms
S. Westwood, A. Gojova, B. Kuo, A. I. Barakat, and B.L. Gray, 2007, Proc. of SPIE, 6465 pp. S1-S8.

Modulation of ATP/ADP Concentration at the Endothelial Surface by Shear Stress: Effect of Flow Recirculation
Hyo Won Choi, Katherine W. Ferrara, and Abdul I. Barkat, 2007, Annals of Biomedical Engineering, 35 pp. 505-516.

Flow-Activated Ion Channels in Vascular Endothelium
Mamta Gautam, Andrea Gojova, and Abdul I. Barkat, 2006, Cell Biochemistry and Biophysics, 46 pp. 277-284.

Flow-activated Chloride Channels in Vascular Endothelium - shear stress sensitivity, desensitization dynamics, and physiological implication
Mamta Gautam, Yue Shen, Twanda L. Thirkill, Gordon C. Douglas, and Abdul I. Barakat, 2006, The Journal of Biological Chemistry, 281(48) pp. 36492-36500.

Secrets of the Code: Do Vascular Endothelial Cells Use Ion Channels to Decipher Complex Flow Signals?
Abdul I. Barakat, Deborah K. Lieu, and Andrea Gojova, 2006, Biomaterials, 27 pp. 671-678.

Numerical Study of the Impact of non-Newtonian Blood Behavior on Flow over a Two-Dimensional Backward Facing Step
Hyo Won Choi and Abdul I. Barakat, 2005, Biorheology, 42 pp. 493-509.

Vacular Endothelial Wound Closure under Shear Stress: Role of Membrane fluidity and flow-sensitive ion channels
Andrea Gojova and Abdul I. Barakat, 2005, Journal of Applied Physiology, 98 pp. 2355-2362.

Trophoblast Migration under Flow is Regulated by Endothleial Cells
Arlen Soghomonians, Abdul I. Barakat, Twanda L. Thirkill, and Gordon C. Douglas, 2005, Biology of Reproduction 73 pp. 14-19.

Computational Study of Fluid Mechanical Disturbance Induced by Endovascular Stents
Taewon Seo, Levanto L. Schachter, and Abdul I. Barakat, 2005, Annals of Biomedical Engineering 33(4) pp. 444-456.

Macaque Trophoblast Migration is Regulated by RANTES
Twanda L. thirkill, Kimberly Lowe, Hemamalini Vedagiri, Thomas N. Blankenship, Abdul. I. Barakat and Gorden C. Douglas, 2005, Experimental Cell Research 305 pp. 355-364.

Modulation of ATP/ADP Concentration at the Endothelial Surface by Shear Stress: Effect of Flow Disturbance
H.W. Choi and A. I. Barakat, 2004, Proceedings of the 26th International Conference of the IEEE EMBS, pp. 5065-5068

Effect of Aqueous Tobacco Smoke Extract and Shear Stress on PECAM-1 Expression and Cell Motility in Human Uterine Endothelial Cells
Arlen Soghomonians, Twada L. Thirkill, Natalie F. Marino, Abdul I. Barakat, and Gordon C. Douglas, 2004, Toxicological Sciences, 81, pp. 408-418

Regulation of Trophoblast BetaI-Intergrin Expression by Contact with Endothelial Cells
Twada L. Thirkill, Sonia R. Hendren, Arlen Soghomonians, Natalie F. Marino, Abdul I. Barakat, and Gordon C. Douglas, 2004, Cell Communication and Signaling, 2

Numerical Simulations of Fluid Mechanical Interactions between Two Abdominal Aortic Branches
Taedong Kim, Taewon Seo, and Abdul I. Barakat, 2004, Korea-Austrelia Rheology Journal, 16, pp. 75-83

Differential Membrane Potential and Ion Current Responses to Different Types of Shear Stress in Vascular Endothelial Cells
Deborah K. Lieu, Pamela A. Pappone, and Abdul I.  Barakat, 2004, Am J Physiol Cell Physiol, 286, pp. C1367-1375

A Model for Shear Stress Sensing and Transmission in Vascular Endothelial Cells
Bori M. Mazzag, John S. Tamaresis and Abdul. I. Barakat, 2003, Biophysical Journal, 84, pp. 4087-4101

Different Responsiveness of Vascular Endothelial Cells to Different Types of Fluid Mechanical Shear Stress
Abdul. I. Barakat  Deborah K. Lieu, 2003, Cell Biochemistry and Biophysics, 38, pp. 323-343

Unsteady and three-dimensional simulation of blood flow in the human aortic arch
N. Shahcheraghi, H.A. Dewyer, A.Y. Cheer, A. I. Barakat, T. Rutaganira, 2002, Journal of Biomechanical Engineering, 124, pp. 378-387

Microchannel flatform for the study of endothelial cell shape and function
Bonnie L. Gray, Deborah K. Lieu, Scott D. Collins, Rosemary L. Smith, and Abdul I. Barakat, 2002, Biomedical Microdevices, 4:1, pp. 9-16

Effect of shear stress on migration and integrin expression in macaque trophoblast cells
Arlen Soghomonians, Abdul I. Barakat, Twanda L. Thirkill, Thosmas N. Blankenship, Gondon C. Douglas, 2002, Biochimica et Biophysica Acta, 1589, pp. 233-246

Endothelial cellular response to altered shear stress
Fisher Aron B., Shu Chien, Abdul I. Barakat, and Robert M. Nerem, 2001, Am. J. Physiol. Lung Cell Mol. Physiol., 281, L529-L533

A Model for Shear Stress-induced Deformation of a Flow Sensor on the Surface of Vascular Endothelial Cells
Barakat AI., 2001, J. theor. Biol., 210, pp. 221-236

Flow-induced expression of endothelial Na-K-Cl cotransport: dependence on K+ and Cl- channels
Suvatne J, Barakat AI, O'Donnell ME., 2001, Am. J. Physiol. Cell Physiol., 280, pp. C216-C227

Modulation of ATP/ADP Concentration at the Endothelial Surface by Shear Stress: Effect of Flow-Induced ATP Release
Karin John and Abdul I. Barakat, 2001, Annals of Biomedical Engineering, 29, pp. 740-751

Influence of Different Forms of Fluid Shear Stress on Vascular Endothelial Cell TGF-¡Ía1 mRNA expression
Richard M. Lim, Lynn M. Wiley and Abdul. I. Barakat, 2000, International Journal of Molecular Medicine, 5, pp. 635-641

Numerical simulation of fluid mechanical disturbance induced by intravascular stents.
Barakat AI, Cheng ET., 2000, Proceedings of ICMMB-11

A Flow-Activated Chloride-Selective Membrane Current in Vascular Endothelial Cells
Barakat AI, Leaver EV, Pappone PA, Davies PF., 1999, Circ. Res., 85, pp. 820-828

Responsiveness of vascular endothelium to shear stress: Potential role of ion channels and cellular cytoskeleton (Review)
Abdul I. Barakat, 1999, International Journal of Molecular Medicine, 4, pp. 323-332

Computational study of the effect of geometric and flow parameters on the steady flow field at the rabbit aorto-celiac bifurcation
Cheer AY, Dwyer HA, Barakat AI, Sy E, Bice M, 1998, Biorheology, 35:6, pp. 415-435

Mechanisms of Shear Stress Transmission and Transduction in Endothelial Cells
Barakat AI, Davies PF, 1998, Chest, 114, pp. 58S-63S

Spacial Relationships in Early Signaling Events of Flow-Mediated Endothelial Mechanotransduction
Davies PF, Barbee KA, Volin MV, Robotewskyj A, Chen J, Joseph L, Griem M, Wernick M, Jacobs E, Polacek DC, DePaola N, Barakat AI., 1997, Annu. Rev. Physiol., 59, 527-549  

Measurements of FLow Rates Through Aortic Branches in the Anesthetized Rabbit
Barakat AI, Marini RP, Colton CK, 1997, Laboratory Animal Science, 47:2

Microcinematographic Studies of Flow Patterns in the Excised Rabbit Aorta and its Major Branches
Abdul I. Barakat, Takeshi Karino, Clark K. Colton, 1997, Biorheology, 34, pp. 195-221

Topographical Mapping of Sites of Enhanced HRP Permeability in the Normal Rabbit Aorta
A.I. Barakat, P.A.F. Uhthoff, C.K. Colton, 1992, Journal of Biomechanical Engineering, 114, pp. 283-292

Abstracts :

COMPUTATIONAL STUDY OF ARTERIAL FLOW DISTURBANCE INDUCED BY INTRAVASCULAR STENTS, Levanto G. Schachter, Abdul I. Barakat, 2001, ASME 2001 Bioengineering Conference, BED-vol. 50

MICRODEVICE FOR NON-INVASIVE CONTROL OF ENDOTHELIAL CELL SHAPE
Bonnie L. Gray , Rosemary L. Smith , Deborah K. Lieu, Scott D. Collins , Abdul I. Barakat, 2001, ASME 2001 Bioengineering Conference, BED-vol. 50

DIFFERENTIAL REGULATION OF ENDOTHELIAL TGF-beta1 mRNA EXPRESSION BY DIFFERENT FORMS OF LAMINAR SHEAR STRESS.
R.M. Lum, G.E. Withers III, L.M. Wiley and A.I. Barakat.

SHEAR STRESS-ACTIVATED CHLORIDE-SELECTIVE MEMBRANE CURRENT IN VASCULAR ENDOTHELIAL CELLS.
E. Clark, P. Pappone, and A.I. Barakat.

EFFECT OF CYTOSKELETAL REORGANIZATION ON FLOW-INDUCED MEMBRANE POTENTIAL CHANGES IN ENDOTHELIAL CELLS.
Abdul I. Barakat and Peter F. Davies

A MODEL FOR SHEAR STRESS-INDUCED DEFORMATION OF A FLOW SENSOR ON THE SURFACE OF VASCULAR ENDOTHELIAL CELLS
Abdul I. Barakat and Barbara C. Mazzag

MECHANISMS OF SHEAR STRESS SENSING AND TRANSDUCTION IN VASCULAR ENDOTHELIAL CELLS
Abdul I. Barakat

REGULATION AND ADAPTATION OF SHEAR STRESS-SENSITIVE ION CHANNELS IN VASCULAR ENDOTHELIAL CELLS
D.K. Lieu, P.A. Pappone, and A.I. Barakat

G PROTEINS MEDIATE ION CHANNEL RESPONSES TO SHEAR STRESS IN VASCULAR ENDOTHELIAL CELLS
D.K. Lieu, P.A. Pappone, and A.I. Barakat

VISCOELASTIC PROPERTIES OF CULTURED BOVINE AORTIC ENDOTHELIAL CELLS
Y. F. Kimura, C. W. Hwang, D. K. Lieu, A.I. Barakat, M. Longo

LAMINAR SHEAR STRESS-INDUCED Na-K-2Cl COTRANSPORT EXPRESSION: DEPENDENCE ON K AND Cl CHANNELS
Martha E. O¢®?Donnell, Jimmy Suvatne and Abdul I. Barakat

EFFECT OF DIFFERENT FORMS OF LAMINAR SHEAR STRESS ON TGF-beta1 mRNA EXPRESSION IN ENDOTHELIAL CELLS.
A.I. Barakat, R.M. Lum, G.E. Withers III, and L.M. Wiley

SHEAR STRESS ACTIVATES A CHLORIDE-SELECTIVE MEMBRANE CURRENT IN VASCULAR ENDOTHELIAL CELLS
A. I. Barakat, E.V.M. Clark, P.A. Pappone, and P.F. Davies

SHEAR STRESS ACTIVATES A CHLORIDE-SELECTIVE MEMBRANE CURRENT IN VASCULAR ENDOTHELIAL CELLS
A.I. Barakat, E. Clark, P.A. Pappone, and P.F. Davies

MECHANISMS OF SHEAR STRESS SENSING AND TRANSDUCTION IN VASCULAR ENDOTHELIAL CELLS.
Barakat AI.

 

 

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